Sewanee: Scholarship Sewanee 2015
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Item Coon's Labyrinth Cave Biological Survey(University of the South, 2015-04-24) Steinmann, HaliCaves present a challenge for researchers interested in quantifying biodiversity. Cave fauna are mostly small and inconspicuous, occupying habitats that are difficult and sometimes impossible for humans to access. Additionally, the sensitivity of cave obligate organisms to disturbance of physical habitat, for example, increased sediment content in streams due to foot traffic, raises concern for the conservation of cave fauna during sampling attempts. In an effort to quantify and better understand the fauna of a Pennington Formation cave on the Domain of the University of the South in Sewanee, Tennessee, we systematically surveyed four selected cave passages in February and April for two consecutive years (2014-2015) and produced a map showing the cave’s morphology, including hydrologic sources, springs, and areas of biologic interest.Item Anti-tumorigenic properties of HDAC inhibition on mammary tumorigenesis(University of the South, 2015-04-24) Philpott, Sydney; De Freitas, Angelica; Brown, Sarah; Summers, AlyssaHistone deacetylases (HDACs) are enzymes that epigenetically modify nucleosomes repressing the transcription of certain genes. HDACs can also modify non-histone target proteins altering their function. Understanding the diverse functions of HDACs has lead to an in depth study of the relationship between HDACs and cancer. Since the increased deacetylation of histones leads to increased cell proliferation, angiogenesis and invasion, the use of HDAC inhibitors (HDACi) may be a new therapeutic strategy. HDACi promotes cell cycle arrest, apoptosis and cell differentiation, while preventing angiogenesis. Previous studies have shown a decrease in cell viability, proliferation, and motility with the use of HDACi. Recent investigations are directed towards elucidating the mechanism through which misregulation of HDACs promotes invasion. Currently, we are investigating the role of HDACi on non-histone target Hsp90 and its subsequent effect on the Her2 s ignaling pathway in mammary tumorigenesis.Item Critical Fail: The Effects of Error Management Training on Critical Thinking(University of the South, 2015-04-24) Carlson, BrittaThis research project looks at the effectiveness of error management training (EMT) on critical thinking skills. EMT is a technique that explicitly encourages learners to make errors under the assumption that students learn better from their mistakes. Students were placed in one of four different training conditions and their mean scores on an argument evaluation test were compared. Students were in one of four groups depending on whether they read or wrote about logical arguments and whether they were exposed to successes or mistakes beforehand. We used argument evaluation as a narrow measurement of critical thinking and we hypothesized that students in the active error condition would learn the most. We also surveyed individual differences of conscientiousness and stress reactivity to determine what types of people were most affected by the different training procedures. Implications for critical thinking training in the college student population are investigated.