The evolution of speech has coincided with the development of music over the course of human history. In spite of this research into the therapeutic potential of music has until recently been scarce. Only recently have researchers began to see the potentials for music as an adjunctive therapy and early findings have indicated this therapy may be effective for treating mood disorders, depression and anxiety. It remains unclear how the brain circuits involved in music listening and music production overlap or interact with brain circuits involved in mood and emotion. Going forward there have been more explorations into the potential power music may yield as a method of treatment. Given the overwhelming state of affairs that surround our daily lives now in the age of COVID a better understanding of how music benefits our wellbeing could be valuable. This review explores studies on the effect of music production and listening on cognitive and behavioral responses and human brain activity, summarizes past music therapy models that have been used in clinical settings, and presents data driven findings that explore the relationship between stress, anxiety and music listening.