Synthesis and Characterization of Potential Anti-Cancer Platinum Complexes with Indazole and its Derivative

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Humeniuk, Yullia
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University of the South , Chemistry Department , Sewanee Senior Honor Theses 2024 , Chemistry , Platinum Complexes , Chemotherapeutics
In 1978, the FDA marked a milestone with the clinical approval of Cisplatin, the pioneering metal-based anticancer chemotherapeutic. Its effectiveness sparked great interest in understanding its behavior and developing new platinum pharmaceuticals. Platinum(II) complexes dominate a majority of drug discovery research to date; however, platinum(IV) complexes have also begun to be explored in the belief that they will allow new therapy avenues with fewer side effects, acting as potential prodrugs. This exploration extends beyond platinum, delving into various metal systems, such as ruthenium. Inspired by the ruthenium anticancer complex (KP1019) and the scarcity of metal complexes featuring indazole, we explore the chemistry of platinum-indazole complexes. In recent years, our group yielded a library of new bisindazole Pt(IV) and Pt(II) complexes, enriching the landscape of potential anti-cancer agents. These complexes have been characterized via spectroscopy and crystallography, and the initial experiments suggest at least one new compound interacts with a DNA model.