Synthesis of Various Sulfur and Selenium Complexes and an Investigation of a Multitude of Biological Applications

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Authors
Giesen, Joseph
Miles, Deon T.
Underwood, Christopher
Kimani, Martin
Brumaghim, Julia
Issue Date
2010-05-05
Type
Thesis
Keywords
Department of Chemistry, University of the South , Department of Chemistry, Clemson University , Sewanee, Tennessee , Sulfur , Selenium , Quantum Dot , Nanoscience , Iron , Copper , Thiolate , Crown ether
Abstract
Sulfur and selenium have been used with various biological applications. One line of research utilizes the electron scavenging potential of early chalcogens. Sulfur-containing antioxidants have been shown to mitigate stress and damage cause by radical oxygenated species (ROS) through metal binding. To determine the effect sulfur has on chelated Fe(II) and Cu(I) species, trinitrogen ligands tris(3,5-dimethylpyrazolyl)borate (Tp*) and tris(3,5-dimethylpyrazolyl)methane (Tpm*), were chosen since Tp* and Tpm* are commonly used in biometallic complexes. Synthesis of novel iron complexes (1) and the copper analogs (2) (Figure 1) were attempted and these complexes have since been tested to determine their affect on the reduction potentials of iron and copper via cyclic voltammetry (CV). Secondly, cadmium selenide thiol-protected quantum dots are fluoresencent nanoparticles. Crown ethers (CE) were attached to the semiconducting core through a place-exchange reaction with the protecting thiol. The change in fluorescence was measured with addition of potassium ions (K+). An expected shift in the emission wavelength was seen upon linking of the QDs by ester linkage and is expected for the sequestering of K+ by CE groups attached to the QDs.
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